Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments
نویسندگان
چکیده
Herbs, food and dietary supplements (HFDS), can interact significantly with anticancer drug treatments via cytochrome p450 isoforms (CYP) CYP3A4, CYP2D6, CYP1A2, CYP2C8. The objective of this review was to assess the influence HFDS compounds on these cytochromes. Interactions CYP activities were searched for 189 herbs products, 72 in Web Knowledge® databases. Analyses made from 140 3125 clinical trials 236 3374 vitro, animal model studies or case reports. 18 found report direct interactions between 9 8 drugs. 21 a major metabolic pathway many All 261 classified their interaction main cytochromes P450 involved metabolism We provided an easy-to-use colour-coded table easily match potential 117
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ژورنال
عنوان ژورنال: Critical Reviews in Oncology Hematology
سال: 2021
ISSN: ['1879-0461', '1040-8428']
DOI: https://doi.org/10.1016/j.critrevonc.2021.103342